› 1q0p

X-ray diffraction
1.8Å resolution

A domain of Factor B

Released:
DOI: 10.2210/pdb1q0p/pdb
PDB entry 1q0p coloured by chain, front view.
PDB entry 1q0p coloured by chain, side view.
PDB entry 1q0p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the A domain from complement factor B reveals an integrin-like open conformation.
Bhattacharya AA, Lupher ML, Staunton DE, Liddington RC
Structure 12 371-8 (2004)
PMID: 15016353

Function and Biology Details

Reaction catalysed: 
Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|- bond in complement component C5 alpha-chain to yield C5a and C5b.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor B Ba fragment Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 25.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00751 (Residues: 254-476; Coverage: 30%)
Gene names: BF, BFD, CFB
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

1 bound ligand:
Ligand MN 1 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P63
Unit cell:
a: 72.56Å b: 72.56Å c: 76.06Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.21 0.259
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Complement and the multifaceted functions of VWA and integrin I domains.
Springer TA. (2006)
3 more

5 mentions without citation

Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome.
Goicoechea de Jorge et al. (2007)
4 more