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Crystal structure of HNF4a LBD in complex with the ligand and the coactivator SRC-1 peptide

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00104
Domain description: Ligand-binding domain of nuclear hormone receptor
Occurring in:
  1. Hepatocyte nuclear factor 4-alpha
The deposited structure of PDB entry 1pzl contains 1 copy of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Hepatocyte nuclear factor 4-alpha. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001723
Domain description: Nuclear hormone receptor
Occurring in:
  1. Hepatocyte nuclear factor 4-alpha
IPR000536
Domain description: Nuclear hormone receptor, ligand-binding domain
Occurring in:
  1. Hepatocyte nuclear factor 4-alpha
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Hepatocyte nuclear factor 4-alpha
IPR013809
Domain description: ENTH domain
Occurring in:
  1. Nuclear receptor coactivator 1

Structure domain

CATH CATH domain
1.10.565.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Retinoid X Receptor
Homology: Retinoid X Receptor
Occurring in:
  1. Hepatocyte nuclear factor 4-alpha
The deposited structure of PDB entry 1pzl contains 1 copy of CATH domain 1.10.565.10 (Retinoid X Receptor) in Hepatocyte nuclear factor 4-alpha. Showing 1 copy in chain A.
SCOP SCOP annotations
48683
Class: Peptides
Fold: Nuclear receptor coactivator Src-1
Superfamily: Nuclear receptor coactivator Src-1
Occurring in:
  1. Nuclear receptor coactivator 1
The deposited structure of PDB entry 1pzl contains 1 copy of SCOP domain 48683 (Nuclear receptor coactivator Src-1) in Nuclear receptor coactivator 1. Showing 1 copy in chain B.
48509
Class: All alpha proteins
Fold: Nuclear receptor ligand-binding domain
Superfamily: Nuclear receptor ligand-binding domain
Occurring in:
  1. Hepatocyte nuclear factor 4-alpha
The deposited structure of PDB entry 1pzl contains 1 copy of SCOP domain 48509 (Nuclear receptor ligand-binding domain) in Hepatocyte nuclear factor 4-alpha. Showing 1 copy in chain A.

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