Function and Biology

REFINED STRUCTURE OF THE PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE FROM LACTOBACILLUS 30A

Source organism: Lactobacillus sp. 30A
Biochemical function: histidine decarboxylase activity
Biological process: histidine metabolic process
Cellular component: not assigned

EC 4.1.1.22: Histidine decarboxylase

Reaction catalysed:
L-histidine = histamine + CO(2).
Systematic name:
L-histidine carboxy-lyase (histamine-forming)
Alternative Name(s):
  • L-histidine decarboxylase
  • L-histidine carboxy-lyase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotations
IPR003427
Domain description: Histidine decarboxylase proenzyme
Occurring in:
  1. Histidine decarboxylase beta chain
  2. Histidine decarboxylase alpha chain
IPR016104
Domain description: Pyruvoyl-dependent histidine/arginine decarboxylase
Occurring in:
  1. Histidine decarboxylase beta chain
  2. Histidine decarboxylase alpha chain
IPR016105
Domain description: Pyruvoyl-dependent histidine/arginine decarboxylase, 3-layer sandwich domain
Occurring in:
  1. Histidine decarboxylase alpha chain

Structure domains

CATH CATH domains
3.50.20.10
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: Pyruvoyl-Dependent Histidine Decarboxylase; Chain B
Homology: Pyruvoyl-Dependent Histidine Decarboxylase, subunit B
Occurring in:
  1. Histidine decarboxylase alpha chain
1 copy of CATH domain 3.50.20.10 (Pyruvoyl-Dependent Histidine Decarboxylase; Chain B) in Histidine decarboxylase alpha chain in PDB 1pya.
4.10.510.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Pyruvoyl-Dependent Histidine Decarboxylas; Chain A
Homology: Pyruvoyl-Dependent Histidine Decarboxylas, subunit A
Occurring in:
  1. Histidine decarboxylase beta chain
1 copy of CATH domain 4.10.510.10 (Pyruvoyl-Dependent Histidine Decarboxylas; Chain A) in Histidine decarboxylase beta chain in PDB 1pya.
SCOP SCOP annotation
56272
Class: Alpha and beta proteins (a+b)
Fold: Pyruvoyl-dependent histidine and arginine decarboxylases
Superfamily: Pyruvoyl-dependent histidine and arginine decarboxylases
Occurring in:
  1. Histidine decarboxylase beta chain
  2. Histidine decarboxylase alpha chain
0 copies of SCOP domain 56272 (Histidine decarboxylase) in Histidine decarboxylase alpha chain in PDB 1pya.
1 copy of SCOP domain 56272 (Histidine decarboxylase) in Histidine decarboxylase beta chain in PDB 1pya.