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THE REFINED 1.9 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN: INTERACTION WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE AND SIGNIFICANCE OF THE TYR-PRO-PRO-TRP INSERTION SEGMENT

X-ray diffraction
1.92Å resolution
PDB entry 1ppb coloured by chain, front view.
PDB entry 1ppb coloured by chain, side view.
PDB entry 1ppb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: alpha-thrombin complex
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Multimeric state: hetero dimer
Accessible surface area: 13332.07 Å2
Buried surface area: 2776.74 Å2
Dissociation area: 1,388.37 Å2
Dissociation energy (ΔGdiss): 11.73 kcal/mol
Dissociation entropy (TΔSdiss): 10.47 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133055
Complex Portal ID: CPX-6222

Macromolecules

Thrombin light chain
Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Pfam: Thrombin light chain
InterPro:
SCOP: Eukaryotic proteases
Thrombin light chain in PDB entry 1ppb, assembly 1, front view.
Thrombin light chain in PDB entry 1ppb, assembly 1, side view.
Thrombin light chain in PDB entry 1ppb, assembly 1, top view.
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Thrombin heavy chain
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Thrombin heavy chain in PDB entry 1ppb, assembly 1, front view.
Thrombin heavy chain in PDB entry 1ppb, assembly 1, side view.
Thrombin heavy chain in PDB entry 1ppb, assembly 1, top view.
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