› 1pos

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF A NOVEL DISULFIDE-LINKED "TREFOIL" MOTIF FOUND IN A LARGE FAMILY OF PUTATIVE GROWTH FACTORS

Released:
DOI: 10.2210/pdb1pos/pdb
PDB entry 1pos coloured by chain, front view.
PDB entry 1pos coloured by chain, side view.
PDB entry 1pos coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors.
De A, Brown DG, Gorman MA, Carr M, Sanderson MR, Freemont PS
Proc Natl Acad Sci U S A 91 1084-8 (1994)
PMID: 8302836

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134269 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trefoil factor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 106 amino acids
Theoretical weight: 11.74 KDa
Source organism: Sus scrofa
Expression system: Not provided
UniProt:
  • Canonical: P01359 (Residues: 22-127; Coverage: 100%)
Gene names: SML1, TFF2
Sequence domains: Trefoil (P-type) domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 2 x PCA

Experiments and Validation Details

Entry percentile scores
Spacegroup: I212121
Unit cell:
a: 181.68Å b: 54.69Å c: 72.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.219 not available
Expression system: Not provided

Quick links

Citations

11 review citations

Trefoil factors: initiators of mucosal healing.
Taupin et al. (2003)
10 more

2 mentions without citation

A base measure of precision for protein stability predictors: structural sensitivity.
Caldararu et al. (2021)
1 more