PDBe 1pii

X-ray diffraction
2Å resolution

THREE-DIMENSIONAL STRUCTURE OF THE BIFUNCTIONAL ENZYME PHOSPHORIBOSYLANTHRANILATE ISOMERASE: INDOLEGLYCEROLPHOSPHATE SYNTHASE FROM ESCHERICHIA COLI REFINED AT 2.0 ANGSTROMS RESOLUTION

Released:

Function and Biology Details

Reactions catalysed:
N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1- deoxy-D-ribulose 5-phosphate. 
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C- (3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptophan biosynthesis protein TrpCF Chain: A
Molecule details ›
Chain: A
Length: 452 amino acids
Theoretical weight: 49.41 KDa
Source organism: Escherichia coli
Expression system: Not provided
UniProt:
  • Canonical: P00909 (Residues: 2-453; Coverage: 100%)
Gene names: JW1254, b1262, trpC, trpF
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41
Unit cell:
a: 104.7Å b: 104.7Å c: 68Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 not available not available
Expression system: Not provided