PDBe 1pgf

X-ray diffraction
4.5Å resolution

PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), CIS MODEL

Released:

Function and Biology Details

Reaction catalysed:
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin G/H synthase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 576 amino acids
Theoretical weight: 66.16 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: P05979 (Residues: 25-600; Coverage: 100%)
Gene names: COX1, PTGS1
Sequence domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: I222
Unit cell:
a: 99.22Å b: 208.99Å c: 232.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.254 0.254 0.267