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Crystal structure of the complex of apopain with the tetrapeptide aldehyde inhibitor AC-DEVD-CHO

Source organism: Homo sapiens
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.22.56: Caspase-3

Reaction catalysed:
Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position
Systematic name:
-
Alternative Name(s):
  • Apopain
  • CASP-3
  • CPP32
  • Yama protein

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00656
Domain description: Caspase domain
Occurring in:
  1. Caspase-3 subunit p17
  2. Caspase-3 subunit p12
The deposited structure of PDB entry 1pau contains 1 copy of Pfam domain PF00656 (Caspase domain) in Caspase-3 subunit p17. Showing 1 copy in chain A.
The deposited structure of PDB entry 1pau contains 1 copy of Pfam domain PF00656 (Caspase domain) in Caspase-3 subunit p12. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR015917
Domain description: Peptidase C14A, caspase catalytic domain
Occurring in:
  1. Caspase-3 subunit p17
  2. Caspase-3 subunit p12
IPR011600
Domain description: Peptidase C14, caspase domain
Occurring in:
  1. Caspase-3 subunit p17
  2. Caspase-3 subunit p12
IPR029030
Domain description: Caspase-like domain superfamily
Occurring in:
  1. Caspase-3 subunit p17
  2. Caspase-3 subunit p12
IPR002138
Domain description: Peptidase C14, caspase non-catalytic subunit p10
Occurring in:
  1. Caspase-3 subunit p12
IPR033139
Domain description: Peptidase family C14A, cysteine active site
Occurring in:
  1. Caspase-3 subunit p17
IPR016129
Domain description: Peptidase family C14A, His active site
Occurring in:
  1. Caspase-3 subunit p17
IPR001309
Domain description: Peptidase C14, p20 domain
Occurring in:
  1. Caspase-3 subunit p17
IPR002398
Domain description: Peptidase C14 family
Occurring in:
  1. Caspase-3 subunit p17

Structure domains

CATH CATH domains
3.30.70.1470
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Caspase-like
Occurring in:
  1. Caspase-3 subunit p12
The deposited structure of PDB entry 1pau contains 1 copy of CATH domain 3.30.70.1470 (Alpha-Beta Plaits) in Caspase-3 subunit p12. Showing 1 copy in chain B.
3.40.50.1460
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Caspase-3 subunit p17
The deposited structure of PDB entry 1pau contains 1 copy of CATH domain 3.40.50.1460 (Rossmann fold) in Caspase-3 subunit p17. Showing 1 copy in chain A.
SCOP SCOP annotation
52130
Class: Alpha and beta proteins (a/b)
Fold: Caspase-like
Superfamily: Caspase-like
Occurring in:
  1. Caspase-3 subunit p17
  2. Caspase-3 subunit p12
The deposited structure of PDB entry 1pau contains 1 copy of SCOP domain 52130 (Caspase catalytic domain) in Caspase-3 subunit p17. Showing 1 copy in chain A.

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