PDBe 1p7c

X-ray diffraction
2.1Å resolution

Crystal Structure of HSV1-TK complexed with TP5A


Function and Biology Details

Reaction catalysed:
ATP + thymidine = ADP + thymidine 5'-phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Thymidine kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 343 amino acids
Theoretical weight: 37.21 KDa
Source organism: Herpes simplex virus (type 1 / strain 17)
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P03176 (Residues: 34-376; Coverage: 91%)
Gene names: TK, UL23
Sequence domains: Thymidine kinase from herpesvirus
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: C2221
Unit cell:
a: 113.219Å b: 117.847Å c: 108.4Å
α: 90° β: 90° γ: 90°
R R work R free
0.244 0.239 0.285
Expression system: Escherichia coli BL21(DE3)