› 1p6f

X-ray diffraction
2.2Å resolution

Structure of the human natural cytotoxicity receptor NKp46

Released:
DOI: 10.2210/pdb1p6f/pdb
PDB entry 1p6f coloured by chain, front view.
PDB entry 1p6f coloured by chain, side view.
PDB entry 1p6f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors.
Foster CE, Colonna M, Sun PD
J Biol Chem 278 46081-6 (2003)
PMID: 12960161

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131189 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Natural cytotoxicity triggering receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 27.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O76036 (Residues: 22-263; Coverage: 86%)
Gene names: LY94, NCR1
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P61
Unit cell:
a: 85.731Å b: 85.731Å c: 59.52Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.207 0.251
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

Activating natural cytotoxicity receptors of natural killer cells in cancer and infection.
Koch et al. (2013)
15 more

9 mentions without citation

Structural basis for recognition of cellular and viral ligands by NK cell receptors.
Li et al. (2014)
8 more