PDBe 1p4r

X-ray diffraction
2.55Å resolution

Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD

Released:

Function and Biology Details

Reactions catalysed:
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide. 
IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional purine biosynthesis protein PURH Chains: A, B
Molecule details ›
Chains: A, B
Length: 592 amino acids
Theoretical weight: 64.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31939 (Residues: 1-592; Coverage: 100%)
Gene names: ATIC, OK/SW-cl.86, PURH
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 83.595Å b: 93.035Å c: 164.192Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.189 0.257
Expression system: Escherichia coli