› 1p1o

X-ray diffraction
1.6Å resolution

Crystal structure of the GluR2 ligand-binding core (S1S2J) mutant L650T in complex with quisqualate

Released:
DOI: 10.2210/pdb1p1o/pdb
PDB entry 1p1o coloured by chain, front view.
PDB entry 1p1o coloured by chain, side view.
PDB entry 1p1o coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes.
Armstrong N, Mayer M, Gouaux E
Proc Natl Acad Sci U S A 100 5736-41 (2003)
PMID: 12730367

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 29.21 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand QUS 1 x QUS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21212
Unit cell:
a: 63.978Å b: 90.865Å c: 47.311Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.204 0.235
Expression system: Escherichia coli BL21

Quick links

Citations

21 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
20 more

2 mentions without citation

Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes.
Armstrong et al. (2003)
1 more