PDBe 1p14

X-ray diffraction
1.9Å resolution

Crystal structure of a catalytic-loop mutant of the insulin receptor tyrosine kinase

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin receptor subunit beta Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06213 (Residues: 1005-1310; Coverage: 23%)
Gene name: INSR
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P212121
Unit cell:
a: 57.472Å b: 69.482Å c: 88.814Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.224 0.24
Expression system: Spodoptera frugiperda