PDBe 1oy9

X-ray diffraction
3.8Å resolution

Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump


Function and Biology Details

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Multidrug efflux pump subunit AcrB Chain: A
Molecule details ›
Chain: A
Length: 1049 amino acids
Theoretical weight: 113.67 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
  • Canonical: P31224 (Residues: 1-1049; Coverage: 100%)
Gene names: JW0451, acrB, acrE, b0462
Sequence domains: AcrB/AcrD/AcrF family
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: R32
Unit cell:
a: 144.676Å b: 144.676Å c: 517.512Å
α: 90° β: 90° γ: 120°
R R work R free
0.286 0.283 0.344
Expression system: Escherichia coli