PDBe 1ovl

X-ray diffraction
2.2Å resolution

Crystal Structure of Nurr1 LBD

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor subfamily 4 group A member 2 Chains: B, C, E, F
Molecule details ›
Chains: B, C, E, F
Length: 271 amino acids
Theoretical weight: 30.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43354 (Residues: 328-598; Coverage: 45%)
Gene names: NOT, NR4A2, NURR1, TINUR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor subfamily 4 group A member 2 Chains: A, D
Molecule details ›
Chains: A, D
Length: 271 amino acids
Theoretical weight: 30.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43354 (Residues: 328-598; Coverage: 45%)
Gene names: NOT, NR4A2, NURR1, TINUR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P31
Unit cell:
a: 80.383Å b: 80.383Å c: 227.37Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.231 0.217 0.259
Expression system: Escherichia coli