PDBe 1osh

X-ray diffraction
1.8Å resolution

A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bile acid receptor Chain: A
Molecule details ›
Chain: A
Length: 232 amino acids
Theoretical weight: 27.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96RI1 (Residues: 257-486; Coverage: 47%)
Gene names: BAR, FXR, HRR1, NR1H4, RIP14
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P212121
Unit cell:
a: 36.656Å b: 56.776Å c: 117.646Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.215 0.234
Expression system: Escherichia coli BL21(DE3)