PDBe 1oro

X-ray diffraction
2.4Å resolution

A FLEXIBLE LOOP AT THE DIMER INTERFACE IS A PART OF THE ACTIVE SITE OF THE ADJACENT MONOMER OF ESCHERICHIA COLI OROTATE PHOSPHORIBOSYLTRANSFERASE

Released:

Function and Biology Details

Reaction catalysed:
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Orotate phosphoribosyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 213 amino acids
Theoretical weight: 23.59 KDa
Source organism: Escherichia coli
UniProt:
  • Canonical: P0A7E3 (Residues: 1-213; Coverage: 100%)
Gene names: JW3617, b3642, pyrE
Sequence domains: Phosphoribosyl transferase domain
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 54.87Å b: 71.08Å c: 104.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.183 not available