PDBe 1opl

X-ray diffraction
3.42Å resolution

Structural basis for the auto-inhibition of c-Abl tyrosine kinase

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 537 amino acids
Theoretical weight: 61.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00519 (Residues: 6-12, 13-512; Coverage: 45%)
  • Best match: P00519-2 (Residues: 1-531)
Gene names: ABL, ABL1, JTK7
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2221
Unit cell:
a: 77.017Å b: 273.384Å c: 124.384Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.306 0.306 0.315
Expression system: Spodoptera frugiperda