PDBe 1opk

X-ray diffraction
1.8Å resolution

Structural basis for the auto-inhibition of c-Abl tyrosine kinase

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chain: A
Molecule details ›
Chain: A
Length: 495 amino acids
Theoretical weight: 56.19 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00520 (Residues: 27-515; Coverage: 44%)
Gene names: Abl, Abl1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: C2221
Unit cell:
a: 118.328Å b: 123.943Å c: 74.798Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.221
Expression system: Spodoptera frugiperda