Function and Biology

P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase

Source organism: Bos taurus
Biochemical function: phosphatidylinositol 3-kinase regulator activity
Biological process: not assigned
Cellular component: phosphatidylinositol 3-kinase complex

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00017
Domain description: SH2 domain
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
1 copy of Pfam domain PF00017 (SH2 domain) in Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB 1oo3.

InterPro InterPro annotations
IPR000980
Domain description: SH2 domain
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
IPR036860
Domain description: SH2 domain superfamily
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
IPR001720
Domain description: PI3K p85/p55 subunit
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
IPR035022
Domain description: PI3K p85 subunit, N-terminal SH2 domain
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha

Structure domain

CATH CATH domain
3.30.505.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SHC Adaptor Protein
Homology: SH2 domain
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
1 copy of CATH domain 3.30.505.10 (SHC Adaptor Protein) in Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB 1oo3.
SCOP SCOP annotation
55551
Class: Alpha and beta proteins (a+b)
Fold: SH2-like
Superfamily: SH2 domain
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
1 copy of SCOP domain 55551 (SH2 domain) in Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB 1oo3.