PDBe 1ol7

X-ray diffraction
2.75Å resolution

Structure of Human Aurora-A 122-403 phosphorylated on Thr287, Thr288

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis of Aurora-A activation by TPX2 at the mitotic spindle.
Mol. Cell 12 851-62 (2003)
PMID: 14580337

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 282 amino acids
Theoretical weight: 32.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14965 (Residues: 122-403; Coverage: 70%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P6122
Unit cell:
a: 81.18Å b: 81.18Å c: 169.62Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.257 0.257 0.296
Expression system: Escherichia coli