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Crystal structure of the Nco-A1 PAS-B domain bound to the STAT6 transactivation domain LXXLL motif

X-ray diffraction
2.21Å resolution
PDB entry 1oj5 coloured by chain, front view.
PDB entry 1oj5 coloured by chain, side view.
PDB entry 1oj5 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Signal transducer and activator of transcription 6 and Nuclear receptor coactivator 1
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Multimeric state: hetero dimer
Accessible surface area: 7022.81 Å2
Buried surface area: 1571.87 Å2
Dissociation area: 447.31 Å2
Dissociation energy (ΔGdiss): 0.04 kcal/mol
Dissociation entropy (TΔSdiss): 7.66 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154571

Macromolecules

Nuclear receptor coactivator 1
Chain: A
Length: 132 amino acids
Theoretical weight: 14.81 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P70365 (Residues: 256-385; Coverage: 9%)
Gene names: Ncoa1, Src1
Pfam: PAS domain
InterPro:
CATH: PAS domain
SCOP: PAS domain of steroid receptor coactivator 1A, NCo-A1
Nuclear receptor coactivator 1 in PDB entry 1oj5, assembly 1, front view.
Nuclear receptor coactivator 1 in PDB entry 1oj5, assembly 1, side view.
Nuclear receptor coactivator 1 in PDB entry 1oj5, assembly 1, top view.
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Signal transducer and activator of transcription 6
Chain: B
Length: 14 amino acids
Theoretical weight: 1.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P42226 (Residues: 795-808; Coverage: 2%)
Gene name: STAT6
Signal transducer and activator of transcription 6 in PDB entry 1oj5, assembly 1, front view.
Signal transducer and activator of transcription 6 in PDB entry 1oj5, assembly 1, side view.
Signal transducer and activator of transcription 6 in PDB entry 1oj5, assembly 1, top view.
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