PDBe 1oiu

X-ray diffraction
2Å resolution

Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-A2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 260 amino acids
Theoretical weight: 29.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: P20248 (Residues: 174-432)
Gene names: CCN1, CCNA, CCNA2
Cyclin-dependent kinase 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 302 amino acids
Theoretical weight: 34.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: P24941 (Residues: 1-298)
Gene names: CDK2, CDKN2

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 73.648Å b: 133.778Å c: 148.228Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.253
Expression system: Escherichia coli