PDBe 1ohe

X-ray diffraction
2.2Å resolution

Structure of cdc14b phosphatase with a peptide ligand

Released:

Function and Biology Details

Reactions catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate. 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PEPTIDE LIGAND Chain: B
Molecule details ›
Chain: B
Length: 4 amino acids
Theoretical weight: 379 Da
Source organism: Escherichia coli
Expression system: Not provided
Dual specificity protein phosphatase CDC14B Chain: A
Molecule details ›
Chain: A
Length: 348 amino acids
Theoretical weight: 40.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60729 (Residues: 39-386; Coverage: 70%)
Gene name: CDC14B
Sequence domains:
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: C2
Unit cell:
a: 114.76Å b: 53.15Å c: 64.17Å
α: 90° β: 117.48° γ: 90°
R-values:
R R work R free
0.207 0.207 0.253
Expression systems:
  • Not provided
  • Spodoptera frugiperda