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Glutamate Synthase from Synechocystis sp in complex with 2-Oxoglutarate at 2.0 Angstrom resolution

Source organism: Synechocystis sp. PCC 6803
Biochemical function: 3 iron, 4 sulfur cluster binding
Biological process: L-glutamate biosynthetic process
Cellular component: not assigned

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EC 1.4.7.1: Glutamate synthase (ferredoxin)

Reaction catalysed:
(1a) L-glutamate + NH(3) = L-glutamine + H(2)O
Systematic name:
L-glutamate:ferredoxin oxidoreductase (transaminating)
Alternative Name(s):
  • Ferredoxin-dependent glutamate synthase
  • Ferredoxin-glutamate synthase
  • Glutamate synthase (ferredoxin-dependent)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01493
Domain description: GXGXG motif
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
The deposited structure of PDB entry 1ofd contains 2 copies of Pfam domain PF01493 (GXGXG motif) in Ferredoxin-dependent glutamate synthase 2. Showing 1 copy in chain A.

PF01645
Domain description: Conserved region in glutamate synthase
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
The deposited structure of PDB entry 1ofd contains 2 copies of Pfam domain PF01645 (Conserved region in glutamate synthase) in Ferredoxin-dependent glutamate synthase 2. Showing 1 copy in chain A.

PF04898
Domain description: Glutamate synthase central domain
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
The deposited structure of PDB entry 1ofd contains 2 copies of Pfam domain PF04898 (Glutamate synthase central domain) in Ferredoxin-dependent glutamate synthase 2. Showing 1 copy in chain A.

PF00310
Domain description: Glutamine amidotransferases class-II
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
The deposited structure of PDB entry 1ofd contains 2 copies of Pfam domain PF00310 (Glutamine amidotransferases class-II) in Ferredoxin-dependent glutamate synthase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002489
Domain description: Glutamate synthase, alpha subunit, C-terminal
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
IPR036485
Domain description: Glutamate synthase, alpha subunit, C-terminal domain superfamily
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
IPR002932
Domain description: Glutamate synthase domain
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
IPR029055
Domain description: Nucleophile aminohydrolases, N-terminal
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
IPR017932
Domain description: Glutamine amidotransferase type 2 domain
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
IPR006982
Domain description: Glutamate synthase, central-N
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2

Structure domains

CATH CATH domains
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
The deposited structure of PDB entry 1ofd contains 4 copies of CATH domain 3.20.20.70 (TIM Barrel) in Ferredoxin-dependent glutamate synthase 2. Showing 2 copies in chain A.
3.60.20.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homology: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
The deposited structure of PDB entry 1ofd contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Ferredoxin-dependent glutamate synthase 2. Showing 1 copy in chain A.
2.160.20.60
Class: Mainly Beta
Architecture: 3 Solenoid
Topology: Pectate Lyase C-like
Homology: Glutamate synthase, alpha subunit, C-terminal domain
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
The deposited structure of PDB entry 1ofd contains 2 copies of CATH domain 2.160.20.60 (Pectate Lyase C-like) in Ferredoxin-dependent glutamate synthase 2. Showing 1 copy in chain A.
SCOP SCOP annotations
69337
Class: All beta proteins
Fold: Single-stranded right-handed beta-helix
Superfamily: Alpha subunit of glutamate synthase, C-terminal domain
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
The deposited structure of PDB entry 1ofd contains 2 copies of SCOP domain 69337 (Alpha subunit of glutamate synthase, C-terminal domain) in Ferredoxin-dependent glutamate synthase 2. Showing 1 copy in chain A.
51396
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: FMN-linked oxidoreductases
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
The deposited structure of PDB entry 1ofd contains 2 copies of SCOP domain 51396 (FMN-linked oxidoreductases) in Ferredoxin-dependent glutamate synthase 2. Showing 1 copy in chain A.
56236
Class: Alpha and beta proteins (a+b)
Fold: Ntn hydrolase-like
Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Occurring in:
  1. Ferredoxin-dependent glutamate synthase 2
The deposited structure of PDB entry 1ofd contains 2 copies of SCOP domain 56236 (Class II glutamine amidotransferases) in Ferredoxin-dependent glutamate synthase 2. Showing 1 copy in chain A.

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