Function and Biology

Heterodimer of p40phox and p67phox PB1 domains from human NADPH oxidase

Source organism: Homo sapiens
Biochemical function: superoxide-generating NADPH oxidase activator activity
Biological process: respiratory burst
Cellular component: NADPH oxidase complex

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00564
Domain description: PB1 domain
Occurring in:
  1. Neutrophil cytosol factor 2
  2. Neutrophil cytosol factor 4
2 copies of Pfam domain PF00564 (PB1 domain) in Neutrophil cytosol factor 4 in PDB 1oey.
1 copy of Pfam domain PF00564 (PB1 domain) in Neutrophil cytosol factor 2 in PDB 1oey.

InterPro InterPro annotations
IPR000270
Domain description: PB1 domain
Occurring in:
  1. Neutrophil cytosol factor 2
  2. Neutrophil cytosol factor 4
IPR000919
Domain description: Neutrophil cytosol factor P40
Occurring in:
  1. Neutrophil cytosol factor 4
IPR034853
Domain description: Neutrophil cytosol factor P40, PB1 domain
Occurring in:
  1. Neutrophil cytosol factor 4
IPR034885
Domain description: Neutrophil cytosol factor 2, PB1 domain
Occurring in:
  1. Neutrophil cytosol factor 2
IPR034889
Domain description: Neutrophil cytosol factor 2
Occurring in:
  1. Neutrophil cytosol factor 2

Structure domain

CATH CATH domain
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Neutrophil cytosol factor 2
  2. Neutrophil cytosol factor 4
2 copies of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Neutrophil cytosol factor 4 in PDB 1oey.
1 copy of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Neutrophil cytosol factor 2 in PDB 1oey.
SCOP SCOP annotation
64225
Class: Alpha and beta proteins (a+b)
Fold: beta-Grasp (ubiquitin-like)
Superfamily: CAD & PB1 domains
Occurring in:
  1. Neutrophil cytosol factor 2
  2. Neutrophil cytosol factor 4
2 copies of SCOP domain 64225 (PB1 domain) in Neutrophil cytosol factor 4 in PDB 1oey.
1 copy of SCOP domain 64225 (PB1 domain) in Neutrophil cytosol factor 2 in PDB 1oey.