Structure analysis

Heterodimer of p40phox and p67phox PB1 domains from human NADPH oxidase

X-ray diffraction
2Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: hetero dimer
Accessible surface area: 11000 Å2
Buried surface area: 1400 Å2
Dissociation area: 700 Å2
Dissociation energy (ΔGdiss): -1 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -4 kcal/mol
Symmetry number: 1
Assembly 3
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Multimeric state: hetero dimer

Binding statistics and energies are not available for this assembly
Assembly 4
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Multimeric state: hetero dimer
Accessible surface area: 10800 Å2
Buried surface area: 1400 Å2
Dissociation area: 700 Å2
Dissociation energy (ΔGdiss): -4 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -3 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B, C, D
Length: 83 amino acids
Theoretical weight: 9.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19878 (Residues: 350-429; Coverage: 15%)
Gene names: NCF2, NOXA2, P67PHOX
Pfam: PB1 domain
InterPro:
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
SCOP: PB1 domain

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Chains: J, K, L, M
Length: 107 amino acids
Theoretical weight: 12.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15080 (Residues: 237-339; Coverage: 30%)
Gene names: NCF4, SH3PXD4
Pfam: PB1 domain
InterPro:
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
SCOP: PB1 domain

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