PDBe 1oec

X-ray diffraction
2.4Å resolution

FGFr2 kinase domain

Released:
Source organism: Homo sapiens
Entry authors: Ceska TA, Owens R, Doyle C, Hamlyn P, Crabbe T, Moffat D, Davis J, Martin R, Perry MJ

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 36.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P21802 (Residues: 456-768; Coverage: 39%)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: I222
Unit cell:
a: 69.76Å b: 80.5Å c: 120.17Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.211 0.285
Expression system: Spodoptera frugiperda