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Crystal structure of a ternary complex of the human histone methyltransferase SET7/9

Source organism: Homo sapiens
Biochemical function: histone H3K4 monomethyltransferase activity
Biological process: regulation of DNA-templated transcription
Cellular component: chromosome

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EC 2.1.1.364: [Histone H3]-lysine(4) N-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Systematic name:
S-adenosyl-L-methionine:[histone H3]-L-lysine(4) N(6)-methyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00856
Domain description: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase SETD7
The deposited structure of PDB entry 1o9s contains 2 copies of Pfam domain PF00856 (SET domain) in Histone-lysine N-methyltransferase SETD7. Showing 1 copy in chain A.

PF02493
Domain description: MORN repeat
Occurring in:
  1. Histone-lysine N-methyltransferase SETD7
The deposited structure of PDB entry 1o9s contains 2 copies of Pfam domain PF02493 (MORN repeat) in Histone-lysine N-methyltransferase SETD7. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001214
Domain description: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase SETD7
IPR046341
Domain description: SET domain superfamily
Occurring in:
  1. Histone-lysine N-methyltransferase SETD7
IPR044436
Domain description: SETD7, SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase SETD7
IPR017155
Domain description: Histone-lysine N-methyltransferase SETD7
Occurring in:
  1. Histone-lysine N-methyltransferase SETD7

Structure domains

CATH CATH domains
2.170.270.10
Class: Mainly Beta
Architecture: Beta Complex
Topology: Beta-clip-like
Homology: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase SETD7
The deposited structure of PDB entry 1o9s contains 2 copies of CATH domain 2.170.270.10 (Beta-clip-like) in Histone-lysine N-methyltransferase SETD7. Showing 1 copy in chain A.
2.20.110.10
Class: Mainly Beta
Architecture: Single Sheet
Topology: Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
Homology: Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
Occurring in:
  1. Histone-lysine N-methyltransferase SETD7
The deposited structure of PDB entry 1o9s contains 2 copies of CATH domain 2.20.110.10 (Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain) in Histone-lysine N-methyltransferase SETD7. Showing 1 copy in chain A.
SCOP SCOP annotations
82200
Class: All beta proteins
Fold: beta-clip
Superfamily: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase SETD7
The deposited structure of PDB entry 1o9s contains 2 copies of SCOP domain 82200 (Histone lysine methyltransferases) in Histone-lysine N-methyltransferase SETD7. Showing 1 copy in chain A.
82186
Class: All beta proteins
Fold: open-sided beta-meander
Superfamily: Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
Occurring in:
  1. Histone-lysine N-methyltransferase SETD7
The deposited structure of PDB entry 1o9s contains 2 copies of SCOP domain 82186 (Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain) in Histone-lysine N-methyltransferase SETD7. Showing 1 copy in chain A.

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