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1.4A CRYSTAL STRUCTURE OF PHOSPHOGLYCERATE MUTASE FROM BACILLUS STEAROTHERMOPHILUS COMPLEXED WITH 2-PHOSPHOGLYCERATE

Source organism: Geobacillus stearothermophilus
Biochemical function: metal ion binding
Biological process: regulation of sporulation
Cellular component: cytosol

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EC 5.4.2.12: Phosphoglycerate mutase (2,3-diphosphoglycerate-independent)

Reaction catalysed:
2-phospho-D-glycerate = 3-phospho-D-glycerate
Systematic name:
D-phosphoglycerate 2,3-phosphomutase (2,3-diphosphoglycerate-independent)
Alternative Name(s):
  • 2,3-diphosphoglycerate-independent phosphoglycerate mutase
  • Cofactor independent phosphoglycerate mutase
  • GriP mutase
  • IPGAM
  • IPGM
  • Monophosphoglycerate mutase
  • Monophosphoglyceromutase
  • PGA mutase
  • PGAM-i
  • Phosphoglycerate phosphomutase
  • Phosphoglyceromutase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF06415
Domain description: BPG-independent PGAM N-terminus (iPGM_N)
Occurring in:
  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
The deposited structure of PDB entry 1o98 contains 1 copy of Pfam domain PF06415 (BPG-independent PGAM N-terminus (iPGM_N)) in 2,3-bisphosphoglycerate-independent phosphoglycerate mutase. Showing 1 copy in chain A.

PF01676
Domain description: Metalloenzyme superfamily
Occurring in:
  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
The deposited structure of PDB entry 1o98 contains 1 copy of Pfam domain PF01676 (Metalloenzyme superfamily) in 2,3-bisphosphoglycerate-independent phosphoglycerate mutase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005995
Domain description: Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent
Occurring in:
  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
IPR036646
Domain description: BPG-independent phosphoglycerate mutase, domain B superfamily
Occurring in:
  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
IPR017850
Domain description: Alkaline-phosphatase-like, core domain superfamily
Occurring in:
  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
IPR011258
Domain description: BPG-independent PGAM, N-terminal
Occurring in:
  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
IPR006124
Domain description: Metalloenzyme
Occurring in:
  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Structure domains

CATH CATH domains
3.40.720.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Alkaline Phosphatase, subunit A
Homology: Alkaline Phosphatase, subunit A
Occurring in:
  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
The deposited structure of PDB entry 1o98 contains 1 copy of CATH domain 3.40.720.10 (Alkaline Phosphatase, subunit A) in 2,3-bisphosphoglycerate-independent phosphoglycerate mutase. Showing 1 copy in chain A.
3.40.1450.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain
Homology: BPG-independent phosphoglycerate mutase, domain B
Occurring in:
  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
The deposited structure of PDB entry 1o98 contains 1 copy of CATH domain 3.40.1450.10 (2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain) in 2,3-bisphosphoglycerate-independent phosphoglycerate mutase. Showing 1 copy in chain A.
SCOP SCOP annotations
64162
Class: Alpha and beta proteins (a/b)
Fold: Alkaline phosphatase-like
Superfamily: Alkaline phosphatase-like
Occurring in:
  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
The deposited structure of PDB entry 1o98 contains 1 copy of SCOP domain 64162 (2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain) in 2,3-bisphosphoglycerate-independent phosphoglycerate mutase. Showing 1 copy in chain A.
64159
Class: Alpha and beta proteins (a/b)
Fold: 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain
Superfamily: 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain
Occurring in:
  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
The deposited structure of PDB entry 1o98 contains 1 copy of SCOP domain 64159 (2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain) in 2,3-bisphosphoglycerate-independent phosphoglycerate mutase. Showing 1 copy in chain A.

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