PDBe 1o6s

X-ray diffraction
1.8Å resolution

Internalin (Listeria monocytogenes) / E-Cadherin (human) Recognition Complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Internalin-A Chain: A
Molecule details ›
Chain: A
Length: 466 amino acids
Theoretical weight: 50.24 KDa
Source organism: Listeria monocytogenes EGD-e
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P0DJM0 (Residues: 35-496; Coverage: 60%)
Gene names: inlA, lmo0433
Sequence domains:
Structure domains:
Cadherin-1 Chain: B
Molecule details ›
Chain: B
Length: 105 amino acids
Theoretical weight: 11.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P12830 (Residues: 155-255; Coverage: 12%)
Gene names: CDH1, CDHE, UVO
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P212121
Unit cell:
a: 55.378Å b: 86.859Å c: 110.723Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.168 0.221
Expression system: Escherichia coli BL21