Structure analysis

CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82209.

X-ray diffraction
1.8Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 6300 Å2
Buried surface area: 850 Å2
Dissociation area: 450 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -2 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 108 amino acids
Theoretical weight: 12.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12931 (Residues: 145-252; Coverage: 20%)
Gene names: SRC, SRC1
Pfam: SH2 domain
InterPro: SH2 domain
CATH: SHC Adaptor Protein
SCOP: SH2 domain

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