PDBe 1o05

X-ray diffraction
2.25Å resolution

Apo form of human mitochondrial aldehyde dehydrogenase

Released:
Source organism: Homo sapiens
Primary publication:
Order and disorder in mitochondrial aldehyde dehydrogenase.
Chem. Biol. Interact. 130-132 3-14 (2001)
PMID: 11306026

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldehyde dehydrogenase, mitochondrial Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 500 amino acids
Theoretical weight: 54.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P05091 (Residues: 18-517; Coverage: 97%)
Gene names: ALDH2, ALDM
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200HB
Spacegroup: P212121
Unit cell:
a: 141.18Å b: 151.94Å c: 177.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.174 0.216
Expression system: Escherichia coli BL21