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Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(H) and Mg2+

Source organism: Homo sapiens
Biochemical function: carboxylesterase activity
Biological process: regulation of serotonin biosynthetic process
Cellular component: extracellular exosome

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EC 1.2.1.3: Aldehyde dehydrogenase (NAD(+))

Reaction catalysed:
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
Systematic name:
Aldehyde:NAD(+) oxidoreductase
Alternative Name(s):
  • CoA-independent aldehyde dehydrogenase
  • NAD-aldehyde dehydrogenase
  • NAD-dependent 4-hydroxynonenal dehydrogenase
  • NAD-dependent aldehyde dehydrogenase
  • NAD-linked aldehyde dehydrogenase
  • Propionaldehyde dehydrogenase
  • m-methylbenzaldehyde dehydrogenase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00171
Domain description: Aldehyde dehydrogenase family
Occurring in:
  1. Aldehyde dehydrogenase, mitochondrial
The deposited structure of PDB entry 1o01 contains 8 copies of Pfam domain PF00171 (Aldehyde dehydrogenase family) in Aldehyde dehydrogenase, mitochondrial. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR016160
Domain description: Aldehyde dehydrogenase, cysteine active site
Occurring in:
  1. Aldehyde dehydrogenase, mitochondrial
IPR016163
Domain description: Aldehyde dehydrogenase, C-terminal
Occurring in:
  1. Aldehyde dehydrogenase, mitochondrial
IPR029510
Domain description: Aldehyde dehydrogenase, glutamic acid active site
Occurring in:
  1. Aldehyde dehydrogenase, mitochondrial
IPR016162
Domain description: Aldehyde dehydrogenase, N-terminal
Occurring in:
  1. Aldehyde dehydrogenase, mitochondrial
IPR015590
Domain description: Aldehyde dehydrogenase domain
Occurring in:
  1. Aldehyde dehydrogenase, mitochondrial
IPR016161
Domain description: Aldehyde/histidinol dehydrogenase
Occurring in:
  1. Aldehyde dehydrogenase, mitochondrial

Structure domains

CATH CATH domains
3.40.605.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aldehyde Dehydrogenase; Chain A, domain 1
Homology: Aldehyde Dehydrogenase; Chain A, domain 1
Occurring in:
  1. Aldehyde dehydrogenase, mitochondrial
The deposited structure of PDB entry 1o01 contains 8 copies of CATH domain 3.40.605.10 (Aldehyde Dehydrogenase; Chain A, domain 1) in Aldehyde dehydrogenase, mitochondrial. Showing 1 copy in chain C.
3.40.309.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aldehyde Dehydrogenase; Chain A, domain 2
Homology: Aldehyde Dehydrogenase; Chain A, domain 2
Occurring in:
  1. Aldehyde dehydrogenase, mitochondrial
The deposited structure of PDB entry 1o01 contains 8 copies of CATH domain 3.40.309.10 (Aldehyde Dehydrogenase; Chain A, domain 2) in Aldehyde dehydrogenase, mitochondrial. Showing 1 copy in chain C.
SCOP SCOP annotation
53721
Class: Alpha and beta proteins (a/b)
Fold: ALDH-like
Superfamily: ALDH-like
Occurring in:
  1. Aldehyde dehydrogenase, mitochondrial
The deposited structure of PDB entry 1o01 contains 8 copies of SCOP domain 53721 (ALDH-like) in Aldehyde dehydrogenase, mitochondrial. Showing 1 copy in chain C.

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