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Ligand binding domain of the human peroxisome proliferator activated receptor gamma in complex with an agonist

X-ray diffraction
2.65Å resolution
PDB entry 1nyx coloured by chain, front view.
PDB entry 1nyx coloured by chain, side view.
PDB entry 1nyx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Peroxisome proliferator-activated receptor gamma
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Multimeric state: homo dimer
Accessible surface area: 25423.43 Å2
Buried surface area: 2849.54 Å2
Dissociation area: 894.51 Å2
Dissociation energy (ΔGdiss): -6.52 kcal/mol
Dissociation entropy (TΔSdiss): 13.28 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-153379

Macromolecules

Peroxisome proliferator-activated receptor gamma
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 230-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Peroxisome proliferator-activated receptor gamma in PDB entry 1nyx, assembly 1, front view.
Peroxisome proliferator-activated receptor gamma in PDB entry 1nyx, assembly 1, side view.
Peroxisome proliferator-activated receptor gamma in PDB entry 1nyx, assembly 1, top view.
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