› 1nx1

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calpain small subunit 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 173 amino acids
Theoretical weight: 19.88 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: P04574 (Residues: 94-266; Coverage: 65%)
Gene names: CAPN4, CAPNS1
Structure domains: EF-hand
Calpastatin Chains: C, D
Molecule details ›
Chains: C, D
Length: 11 amino acids
Theoretical weight: 1.15 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: P12675 (Residues: 231-241; Coverage: 2%)
Gene name: CAST

Ligands and Environments

1 bound ligand:
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 53.746Å b: 61.055Å c: 143.704Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.208 0.253
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Evolutionary families of peptidase inhibitors.
Rawlings et al. (2004)
8 more

8 mentions without citation

The calpains: modular designs and functional diversity.
Croall et al. (2007)
7 more