PDBe 1nuo

X-ray diffraction
3.1Å resolution

Two RTH Mutants with Impaired Hormone Binding

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroid hormone receptor beta Chain: A
Molecule details ›
Chain: A
Length: 261 amino acids
Theoretical weight: 29.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10828 (Residues: 202-461; Coverage: 56%)
Gene names: ERBA2, NR1A2, THR1, THRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P3121
Unit cell:
a: 67.274Å b: 67.274Å c: 130.121Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.257 0.252 0.302
Expression system: Escherichia coli