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Crystal Structure Analysis of the FGF10-FGFR2b Complex

X-ray diffraction
2.9Å resolution
PDB entry 1nun coloured by chain, front view.
PDB entry 1nun coloured by chain, side view.
PDB entry 1nun coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fibroblast growth factor 10 and Fibroblast growth factor receptor 2
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Multimeric state: hetero dimer
Accessible surface area: 16855.65 Å2
Buried surface area: 3133.35 Å2
Dissociation area: 1,425.28 Å2
Dissociation energy (ΔGdiss): 10.59 kcal/mol
Dissociation entropy (TΔSdiss): 12.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127509

Macromolecules

Fibroblast growth factor 10
Chain: A
Length: 145 amino acids
Theoretical weight: 16.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O15520 (Residues: 64-208; Coverage: 85%)
Gene name: FGF10
Pfam: Fibroblast growth factor
InterPro:
CATH: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
SCOP: Fibroblast growth factors (FGF)
Fibroblast growth factor 10 in PDB entry 1nun, assembly 1, front view.
Fibroblast growth factor 10 in PDB entry 1nun, assembly 1, side view.
Fibroblast growth factor 10 in PDB entry 1nun, assembly 1, top view.
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Fibroblast growth factor receptor 2
Chain: B
Length: 230 amino acids
Theoretical weight: 25.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P21802 (Residues: 140-361, 362-368; Coverage: 28%)
Gene names: BEK, FGFR2, KGFR, KSAM
Pfam:
InterPro:
CATH: Immunoglobulins
SCOP: I set domains
Fibroblast growth factor receptor 2 in PDB entry 1nun, assembly 1, front view.
Fibroblast growth factor receptor 2 in PDB entry 1nun, assembly 1, side view.
Fibroblast growth factor receptor 2 in PDB entry 1nun, assembly 1, top view.
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