Function and Biology

The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate

Source organism: Homo sapiens

EC 5.3.1.9: Glucose-6-phosphate isomerase

Reaction catalysed:
Alpha-D-glucose 6-phosphate = beta-D-fructofuranose 6-phosphate
Systematic name:
Alpha-D-glucose-6-phosphate aldose-ketose-isomerase (configuration-inverting)
Alternative Name(s):
  • D-glucose-6-phosphate ketol-isomerase
  • Glucose phosphate isomerase
  • Hexose monophosphate isomerase
  • Hexose phosphate isomerase
  • Hexosephosphate isomerase
  • Oxoisomerase
  • Phosphoglucoisomerase
  • Phosphoglucose isomerase
  • Phosphohexoisomerase
  • Phosphohexomutase
  • Phosphohexose isomerase
  • Phosphosaccharomutase

Sequence family

Pfam Protein family (Pfam)
PF00342
Domain description: Phosphoglucose isomerase
Occurring in:
  1. Glucose-6-phosphate isomerase
The deposited structure of PDB entry 1nuh contains 1 copy of Pfam domain PF00342 (Phosphoglucose isomerase) in Glucose-6-phosphate isomerase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001672
Domain description: Phosphoglucose isomerase (PGI)
Occurring in:
  1. Glucose-6-phosphate isomerase
IPR018189
Domain description: Phosphoglucose isomerase, conserved site
Occurring in:
  1. Glucose-6-phosphate isomerase
IPR023096
Domain description: Phosphoglucose isomerase, C-terminal
Occurring in:
  1. Glucose-6-phosphate isomerase
IPR035482
Domain description: Phosphoglucose isomerase, SIS domain 2
Occurring in:
  1. Glucose-6-phosphate isomerase
IPR035476
Domain description: Phosphoglucose isomerase, SIS domain 1
Occurring in:
  1. Glucose-6-phosphate isomerase
IPR046348
Domain description: SIS domain superfamily
Occurring in:
  1. Glucose-6-phosphate isomerase

Structure domains

CATH CATH domains
3.40.50.10490
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Glucose-6-phosphate isomerase like protein; domain 1
Occurring in:
  1. Glucose-6-phosphate isomerase
The deposited structure of PDB entry 1nuh contains 2 copies of CATH domain 3.40.50.10490 (Rossmann fold) in Glucose-6-phosphate isomerase. Showing 2 copies in chain A.
1.10.1390.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Phosphoglucose isomerase, C-terminal domain
Homology: Phosphoglucose isomerase, C-terminal domain
Occurring in:
  1. Glucose-6-phosphate isomerase
The deposited structure of PDB entry 1nuh contains 1 copy of CATH domain 1.10.1390.10 (Phosphoglucose isomerase, C-terminal domain) in Glucose-6-phosphate isomerase. Showing 1 copy in chain A.
SCOP SCOP annotation
53701
Class: Alpha and beta proteins (a/b)
Fold: SIS domain
Superfamily: SIS domain
Occurring in:
  1. Glucose-6-phosphate isomerase
The deposited structure of PDB entry 1nuh contains 1 copy of SCOP domain 53701 (Phosphoglucose isomerase, PGI) in Glucose-6-phosphate isomerase. Showing 1 copy in chain A.