PDBe 1nsd

X-ray diffraction
1.8Å resolution

INFLUENZA B VIRUS NEURAMINIDASE CAN SYNTHESIZE ITS OWN INHIBITOR

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuraminidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 390 amino acids
Theoretical weight: 43.43 KDa
Source organism: Influenza B virus (STRAIN B/BEIJING/1/87)
Expression system: Not provided
UniProt:
  • Canonical: P27907 (Residues: 76-465; Coverage: 84%)
Gene name: NA
Structure domains: Neuraminidase

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3121
Unit cell:
a: 88.9Å b: 88.9Å c: 222.8Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.169 0.169 not available
Expression system: Not provided