PDBe 1nql

X-ray diffraction
2.8Å resolution

Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor Chain: B
Molecule details ›
Chain: B
Length: 53 amino acids
Theoretical weight: 6.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01133 (Residues: 971-1023; Coverage: 5%)
Gene name: EGF
Sequence domains: EGF-like domain
Structure domains: Laminin
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 624 amino acids
Theoretical weight: 69.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 25-642; Coverage: 52%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: C2
Unit cell:
a: 119.17Å b: 103.66Å c: 101.49Å
α: 90° β: 119.27° γ: 90°
R-values:
R R work R free
0.247 0.241 0.31
Expression systems:
  • Escherichia coli
  • Spodoptera frugiperda