PDBe 1nqc

X-ray diffraction
1.8Å resolution

Crystal structures of Cathepsin S inhibitor complexes


Function and Biology Details

Reaction catalysed:
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|- compound.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cathepsin S Chain: A
Molecule details ›
Chain: A
Length: 217 amino acids
Theoretical weight: 24.02 KDa
Source organism: Homo sapiens
  • Canonical: P25774 (Residues: 115-331; Coverage: 69%)
Gene name: CTSS
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 36.9Å b: 76.5Å c: 101.9Å
α: 90° β: 90° γ: 90°
R R work R free
0.199 0.199 0.219