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Crystal structures of Cathepsin S inhibitor complexes

X-ray diffraction
2Å resolution
PDB entry 1npz coloured by chain, front view.
PDB entry 1npz coloured by chain, side view.
PDB entry 1npz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cathepsin S
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Multimeric state: monomeric
Accessible surface area: 9890.33 Å2
Buried surface area: 886.51 Å2
Dissociation area: 443.26 Å2
Dissociation energy (ΔGdiss): -1.54 kcal/mol
Dissociation entropy (TΔSdiss): 5.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150575
Assembly 2
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Assembly Name: Cathepsin S
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Multimeric state: monomeric
Accessible surface area: 9833.19 Å2
Buried surface area: 899.87 Å2
Dissociation area: 449.93 Å2
Dissociation energy (ΔGdiss): -1.71 kcal/mol
Dissociation entropy (TΔSdiss): 5.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150575

Macromolecules

Cathepsin S
Chains: A, B
Length: 217 amino acids
Theoretical weight: 24.02 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25774 (Residues: 115-331; Coverage: 69%)
Gene name: CTSS
Pfam: Papain family cysteine protease
InterPro:
CATH: Cysteine proteinases
SCOP: Papain-like
Cathepsin S in PDB entry 1npz, assembly 1, front view.
Cathepsin S in PDB entry 1npz, assembly 1, side view.
Cathepsin S in PDB entry 1npz, assembly 1, top view.
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