› 1npu

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1

Released:
DOI: 10.2210/pdb1npu/pdb
PDB entry 1npu coloured by chain, front view.
PDB entry 1npu coloured by chain, side view.
PDB entry 1npu coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural and functional analysis of the costimulatory receptor programmed death-1.
Zhang X, Schwartz JC, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC
Immunity 20 337-47 (2004)
PMID: 15030777

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169695 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death protein 1 Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 13.18 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q02242 (Residues: 34-150; Coverage: 44%)
Gene names: Pd1, Pdcd1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P212121
Unit cell:
a: 23.965Å b: 50.802Å c: 75.278Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.198 0.228
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

107 review citations

PD-1 and its ligands in tolerance and immunity.
Keir et al. (2008)
106 more

15 mentions without citation

Sequence, structure, function, immunity: structural genomics of costimulation.
Chattopadhyay et al. (2009)
14 more