› 1nnt

X-ray diffraction
2.3Å resolution

STRUCTURAL EVIDENCE FOR A PH-SENSITIVE DI-LYSINE TRIGGER IN THE HEN OVOTRANSFERRIN N-LOBE: IMPLICATIONS FOR TRANSFERRIN IRON RELEASE

Released:
DOI: 10.2210/pdb1nnt/pdb
PDB entry 1nnt coloured by chain, front view.
PDB entry 1nnt coloured by chain, side view.
PDB entry 1nnt coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release.
Dewan JC, Mikami B, Hirose M, Sacchettini JC
Biochemistry 32 11963-8 (1993)
PMID: 8218271

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136235 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ovotransferrin Chain: A
Molecule details ›
Chain: A
Length: 328 amino acids
Theoretical weight: 36.11 KDa
Source organism: Gallus gallus
Expression system: Not provided
UniProt:
  • Canonical: P02789 (Residues: 24-351; Coverage: 48%)
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand FE 1 x FE
Ligand CO3 1 x CO3
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 46.94Å b: 91.79Å c: 75.82Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.16 not available
Expression system: Not provided

Quick links

Citations

16 review citations

Transferrin/transferrin receptor-mediated drug delivery.
Li et al. (2002)
15 more

2 mentions without citation

Structure of allergens and structure based epitope predictions.
Dall'antonia et al. (2014)
1 more