› 1nnk

X-ray diffraction
1.85Å resolution

X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.85 A resolution. Crystallization with zinc ions.

Released:
DOI: 10.2210/pdb1nnk/pdb
PDB entry 1nnk coloured by chain, front view.
PDB entry 1nnk coloured by chain, side view.
PDB entry 1nnk coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity.
Lunn ML, Hogner A, Stensbøl TB, Gouaux E, Egebjerg J, Kastrup JS
J Med Chem 46 872-5 (2003)
PMID: 12593667

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 29.22 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand CL 1 x CL
Ligand CE2 1 x CE2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P21212
Unit cell:
a: 54.258Å b: 111.229Å c: 46.643Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 0.245
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
11 more

1 mention without citation

Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors.
Birdsey-Benson et al. (2010)