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N9 NEURAMINIDASE COMPLEXES WITH ANTIBODIES NC41 AND NC10: EMPIRICAL FREE-ENERGY CALCULATIONS CAPTURE SPECIFICITY TRENDS OBSERVED WITH MUTANT BINDING DATA

X-ray diffraction
3Å resolution
PDB entry 1nma coloured by chain, front view.
PDB entry 1nma coloured by chain, side view.
PDB entry 1nma coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Neuraminidase and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero dodecamer
Accessible surface area: 86999.5 Å2
Buried surface area: 34391.66 Å2
Dissociation area: 14,841.2 Å2
Dissociation energy (ΔGdiss): -27.98 kcal/mol
Dissociation entropy (TΔSdiss): 143.95 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-209250

Macromolecules

Neuraminidase
Chain: N
Length: 388 amino acids
Theoretical weight: 43.64 KDa
Source organism: Influenza A virus
UniProt:
  • Canonical: P05803 (Residues: 83-470; Coverage: 83%)
Gene name: NA
Pfam: Neuraminidase
InterPro:
CATH: Neuraminidase
SCOP: Sialidases (neuraminidases)
Neuraminidase in PDB entry 1nma, assembly 1, front view.
Neuraminidase in PDB entry 1nma, assembly 1, side view.
Neuraminidase in PDB entry 1nma, assembly 1, top view.
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FAB NC10
Chain: L
Length: 109 amino acids
Theoretical weight: 12.13 KDa
Source organism: Mus musculus
InterPro:
CATH: Immunoglobulins
SCOP: V set domains (antibody variable domain-like)
FAB NC10 in PDB entry 1nma, assembly 1, front view.
FAB NC10 in PDB entry 1nma, assembly 1, side view.
FAB NC10 in PDB entry 1nma, assembly 1, top view.
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FAB NC10
Chain: H
Length: 122 amino acids
Theoretical weight: 13.42 KDa
Source organism: Mus musculus
InterPro:
CATH: Immunoglobulins
SCOP: V set domains (antibody variable domain-like)
FAB NC10 in PDB entry 1nma, assembly 1, front view.
FAB NC10 in PDB entry 1nma, assembly 1, side view.
FAB NC10 in PDB entry 1nma, assembly 1, top view.
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