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Crystal structure of Myc-Max recognizing DNA

X-ray diffraction
1.8Å resolution
PDB entry 1nkp coloured by chain, front view.
PDB entry 1nkp coloured by chain, side view.
PDB entry 1nkp coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: MYC-MAX transcriptional activator complex and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 16649.09 Å2
Buried surface area: 7958.13 Å2
Dissociation area: 1,481.43 Å2
Dissociation energy (ΔGdiss): 32.43 kcal/mol
Dissociation entropy (TΔSdiss): 11.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-114266
Assembly 2
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Assembly Name: MYC-MAX transcriptional activator complex and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 16266.81 Å2
Buried surface area: 7685.65 Å2
Dissociation area: 1,423.63 Å2
Dissociation energy (ΔGdiss): 27.46 kcal/mol
Dissociation entropy (TΔSdiss): 11.88 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-114266

Macromolecules

Myc proto-oncogene protein
Chains: A, D
Length: 88 amino acids
Theoretical weight: 10.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01106 (Residues: 368-449; Coverage: 18%)
Gene names: BHLHE39, MYC
Pfam:
InterPro:
CATH: Helix-loop-helix DNA-binding domain
SCOP: HLH, helix-loop-helix DNA-binding domain
Myc proto-oncogene protein in PDB entry 1nkp, assembly 1, front view.
Myc proto-oncogene protein in PDB entry 1nkp, assembly 1, side view.
Myc proto-oncogene protein in PDB entry 1nkp, assembly 1, top view.
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Protein max
Chains: B, E
Length: 83 amino acids
Theoretical weight: 9.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61244 (Residues: 23-102; Coverage: 50%)
Gene names: BHLHD4, MAX
Pfam: Helix-loop-helix DNA-binding domain
InterPro:
CATH: Helix-loop-helix DNA-binding domain
SCOP: HLH, helix-loop-helix DNA-binding domain
Protein max in PDB entry 1nkp, assembly 1, front view.
Protein max in PDB entry 1nkp, assembly 1, side view.
Protein max in PDB entry 1nkp, assembly 1, top view.
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DNA chains F, G, H, J
Name: 5'-D(*CP*GP*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*TP*C)-3'
Representative chains: F, G, H, J
Length: 19 nucleotides
Theoretical weight: 5.81 KDa
5'-D(*CP*GP*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*TP*C)-3' in PDB entry 1nkp, assembly 1, front view.
5'-D(*CP*GP*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*TP*C)-3' in PDB entry 1nkp, assembly 1, side view.
5'-D(*CP*GP*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*TP*C)-3' in PDB entry 1nkp, assembly 1, top view.
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