PDBe 1nav

X-ray diffraction
2.5Å resolution

Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroid hormone receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 29.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10827 (Residues: 148-370; Coverage: 46%)
  • Best match: P10827-2 (Residues: 148-408)
Gene names: EAR7, ERBA1, NR1A1, THRA, THRA1, THRA2
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P6522
Unit cell:
a: 109.319Å b: 109.319Å c: 134.652Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.246 0.279
Expression system: Escherichia coli BL21(DE3)