Structure analysis

Crystal Structure of the complex between the Orphan Nuclear Hormone Receptor ROR(alpha)-LBD and Cholesterol

X-ray diffraction
1.63Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 12871.04 Å2
Buried surface area: 922.68 Å2
Dissociation area: 461.34 Å2
Dissociation energy (ΔGdiss): -3.95 kcal/mol
Dissociation entropy (TΔSdiss): 4.69 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152899

Macromolecules

Chain: A
Length: 270 amino acids
Theoretical weight: 31.51 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35398 (Residues: 271-523; Coverage: 48%)
Gene names: NR1F1, RORA, RZRA
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain

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